Objective
The aim of this project is to combine molecular modeling with state-of-the-art medicinal chemistry methods to design and synthesise novel, selective, low molecular weight, substrate-like inhibitors of the MET tyrosine kinase. The Nottingham group is involved in the discovery of new agents that target cell-signaling pathways in order to develop rational chemotherapeutic strategies. Receptor protein kinases have been identified as potential new targets for drug design because of their involvement in cell signaling.
MET kinase is of particular interest, as it does not appear to be expressed in normal tissue thus minimizing the risks of a long-term kinase blockade strategy. To date most strategies aimed at receptor tyrosine kinases have involved blocking the ATP binding site and rely on exploiting differences between relatively well- conserved binding pockets to attain selectivity. The approach that will be taken here is different in that it is the substrate binding sites that will be targeted.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
IHP-MCIF-99-1
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
NOTTIGHAM
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.