Spatial and temporal correlation of signals in t lymphocyte activation

Project Information

Grant agreement ID: HPMF-CT-2002-01541

Project closed

Start date 1 March 2002

End date 29 February 2004

Funded under

• Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002)

Total cost € 118 350,00

EU contribution € 118 350,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Objective

The aim of this interdisciplinary project is the development of a data-driven mathematical model describing the signaling properties of the immunological synapse. The immunological synapse formed between a T cell and an antigen presenting cell is a highly organized state comprising an enormous amount of T cell surface molecules such as the T cell receptor, adhesion molecules (ICAM1, LFA-1) and signaling related molecules (CD2, CD45) . We believe that the spatial organization of the molecules at the interface between T cell and antigen presenting cell plays a key role in antigen recognition. Organizing the T cell receptors ill a synapse results via serial triggering of many T cell receptors in temporal and spatial correlation of signaling events. We will combine numerical data-analysis with mathematical modeling to study this concept mathematically. Numerical data-analysis will use proper orthogonal decomposition and time series analysis. Building on the results of the data-analysis, a mathematical model of the immunological synapse will be developed. The first step in mathematical modeling will be a compartment model of the synapse which will be extended to a detailed spatial model using either partial differential equations or a lattice model (depending on the results of the data-analysis). Such a model will allow us to analyze the correlation of signaling events in the synapse which will explain how transient T cell receptor engagement yields a sustained signal.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• natural sciences › mathematics › pure mathematics › mathematical analysis › differential equations › partial differential equations
• natural sciences › mathematics › applied mathematics › mathematical model

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Programme(s)

• FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002)

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

• EU contribution: No data
• Address: CHU Purpan ; 31024 TOULOUSE ; France
• Total cost: No data