Objective
Understanding, on a molecular level, how genetic information is expressed and how to stimulate or prevent this process is a key step towards the development of new chemotherapeutic strategies. In this framework, dimine transition metal complexes present particularly well-suited photophysical properties to develop new DNA photoprobes. Dinuclear iron (II) and ruthenium (II) complexes have been recently shown to interact very strongly within the DNA grooves and are probably the most promising candidates for such applications. The aim of the project is to deepen the knowledge about the photophysical properties and the interaction with DNA of this class of compounds. More precisely, sequence-selective recognition will be explored through fictionalization of their ligands. Two complementary research approaches will be developed: 1. The in-depth study (including both thermodynamic and kinetic aspects) of the effects of fictionalization of these dinuclear complexes on their interaction with DNA, especially concerning sequence discrimination. 2. The detailed study of the photophysical properties of these fictionalized compounds (including energy and electron transfer between the metal centres) in solution and in the presence of DNA. In both cases, the combination of different powerful spectroscopic methods including linear dichroism and luminescence measurements will be used. Quantum mechanical calculations are also planned to support experimental results interpretation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences inorganic chemistry transition metals
- social sciences sociology social issues social inequalities
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
412 96 GOETEBORG
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.