Objective
Cells use distinct mechanisms to move different classes of RNA from their nuclear site of synthesis to the cytoplasm, including mRNA and U snRNA. Major spliceosomal U snRNAs and mRNAs share similarities in their synthesis : their precursors are transcribed in the nucleus by RNA polymerize II and acquire a m7G cap structure, bound by the nuclear cap-binding complex (CBC). Despite these similarities and the fact that in both cases there are no conserved internal RNA sequences required for nuclear export, U snRNAs and mRNAs are exported in metazoa by different factors. U snRNAs are exported in a complex containing CBC, PHAX (phosphorylated adaptor for RNA export), the export receptor CRM1/Xpo1 and the GTPase Ran. Interestingly, export of mRNAs does not require these factors but depends upon the REF and TAP/NXF1 proteins . Thus , there must be distinguishing features of U snRNAs and mRNAs that are recognized by these cellular factors. One obvious difference is that rnRNA precursors often contain introns whereas u snRNAs do not. It is particularly intriguing to investigate if the presence of an intron can commit a U snRNA to the rnRNA nuclear export pathway and determine if the mRNA specific factors imprinted onto the RNA during splicing can remodel the U1snRNA export. The aim of this project is to understand the molecular mechanisms that determine the two RNA nuclear export pathways and provide new insights as to how the export pathways are distinguished.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.