Objective
The transcription factor AP-1 consist of a variety of dimmers composed of members of the Fos, Jun and ATF families of proteins. The activity of individual AP-1 components is regulated at multiple levels and participate in the regulation of a variety of cellular process including cell proliferation, apoptosis, differentiation and oncogenesis. Mice lacking c-Jun die at midgestation due to liver and heart defects. In addition to AP-1 proteins, c-Jun is capable of interacting with a number of proteins and form a heterotrimer, most notably with the Nuclear Factor of Activated T cells family (NFAT1-4). The binding of AP-1 and NFAT produce a strong coooerative complex cooperation between these unrelated families of transcriptions factors has been implicated in many biological processes in immune cells, but the role in extra-immune tissues remains to be understood. The objectives of this proposal is to clarify the importance of the AP-1/NFAT cooperation in lymphoid cells and to uncover novel biological processes dependent on c-Jun/NFAT interaction in extra-immune tissues, as well as, the requirement of the transactivation activity of c-Jun in these processes. I will generate two transgenic mices with the c-Jun allel mutated.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC2A 3PX LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.