Objective
The control of the final size of an organ and an organism is a fundamental problem in developmental biology. In the last few years, some answers have begun to emerge from Drosophila melanogaster, with the identification of some regulators of cell and tissue growth, Loss-of-function mutations, for the dmyc and cdk4 genes and for genes encoding some components of the insulin-like growth factor pathway (chico, inr, dS6K), produce small flies. In order to identify new regulators of cell and tissue growth, I propose to re-evaluate existing mutants that affect animal size. I will use genetic and genomic information and modern methods of analysis to understand the growth abnormalities in these mutants which were isolated in 30's and 50's by Bridges and Morgan, and Fahmy. A number of these mutants have been lost, suggesting that there may be many more genes to be identified. I will perform a genetic screen on the X chromosome for modifications of the size of a clonal wing compartment. The analysis of these mutants will follow this program: First, I will test if these mutations affect cell or tissue growth and cell cycle progression by clonal analysis in adult appendages and by flow cytometric (FACS) analysis. Second, genes which show interesting phenotypes will be characterized by genetic mapping, molecular cloning and rescue. Third, to confirm their role in the regulation of growth and cell proliferation, I will test if over-expression gives an opposite phenotype to loss of function. Finally, I will examine genetic interactions with pathways known to be involved in the coordination of growth and cell proliferation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences developmental biology
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.