Objective
The SH2-containig inositol 5-phosphase (SHIP2) is a new PtdInsP3 5-phophatase directly involved in insulin sensitivity . The two main objectives of this project are: a ) obtain recombinant SHIP2 in large amounts to develop a rapid assay of activity b ) determine structural infonnation after cristallography . For the first six months, we would like to produce SHIP2 or the catalytic domain of SHIP2 either in baculo-infected cells or in bacteria. Then, for the next six months, we would like to set up a large scale production of the protein. This recombinant protein will be used on the one hand to develop a rapid activity assay , and on the other hand to permit the cristallisation of SHIP2. So, the second year, we would like to obtain cristals of SHIP2, to do the diffraction of the x- rays. The structural detennination of SHIP2, and more particularly of SHIP2 catalytic site will provide tools for structure-based design of selective inhibitors of SHIP2 phosphatase. And these inhibitors will have potential application for the treatment of type II diabete.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences biochemistry biomolecules proteins
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1070 BRUXELLES
Belgium
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