Objective
In the proposed project I will develop a gene network model and a theoretical framework able to integrate basic cellular behaviors and signaling. With it I plan to make a model able to reproduce the morphology and patterns of gene expression of mammalian teeth. General aspects of tooth evolution and development are quite well understood but due to the complexity of mammalian development and morphology, it is difficult to evaluate how genes produce form. A mathematical model allows to integrate information about gene interactions and cellular responses implicated in tooth development into mechanisms whose validity can be tested by comparing predicted and real morphologies. Furthermore, the model can aid to interpret, predict or analyze the possible causes underlying the phenotypic effects of mutations, experimental manipulations and diseases. In Helsinki, a reciprous interaction with a group of experimental developmental biologist will allow me to learn to integrate experimental data into the model while they will profit from a model that may aid to interpret their results and design their experiments and in general in to understand the global coordination of teeth development. We suspect that teeth is a paradigmatic example of developmental systems in which pattern formation and morphogenesis are closely integrated. Our model and the new kind of gene expression and morphology data that Jernvall is developing will provide a useful set of data and methods to evaluate the causal interrelationship between formal and pattern of gene expression. Teeth may be an example development system in which form and pattern are causally interdependent.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00014 Helsinki
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.