Objective
Chemokines constitute a super family of chemo tactic cytokines that play a role in directing the movements of leukocytes within the immune system. Exciting advances during the last year demonstrate a role for these molecules in the targeting of cells to inflammatory sites in a tissue specific manner, and also in tissue specific localisation of malignant cancer cells. So far investigations into chemokine pharmacology have almost exclusively been in vitro studies, and there is a definite need to acquire more biologically relevant information. The aim of this project is therefore to develop and characterise novel tools capable of interacting with the chemokine system, and to evaluate their utility in modulating chemokine signalling and subsequently the disease state.
There are two main project activities.
I. Protein engineering, expression and purification of specific chemokines and homologues.
II. Evaluation in relevant animal models of disease including arthritis, experimental autoimmune encephalitis, chemically induced delayed hypersensitivity and relevant gene knock out models. The chemokines offer a potential novel point of therapeutic intervention and the project will provide important understanding of the therapeutic value of chemokine related therapies in the clinical setting.
Fields of science (EuroSciVoc)
- medical and health sciences clinical medicine rheumatology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pharmacology and pharmacy
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
22007 LUND
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.