Objective
Sepsis and its sequelae remain the leading cause of death in operative intensive care units and a major health economic problem. There is an urgent need for new and reliable diagnostic and prognostic markers to overcome current diagnostic problems in patients with sepsis. In this proposed project therefore
(i) differential gene expression in sepsis will be characterized,
(ii) genes specifically expressed during severe sepsis (but not at the state of infection) will be identified, and
(iii) differences in the expression of selected genes and patterns of nonsurvivors/survivors will be determined. To reach our ambitious aims, state of the art methods, i.e. micro-array based technologies, will be applied in an interdisciplinary setting including collaborations with the Clinic of Anesthesiology and Intensive Care, University of Jena, and the Hans-Knoll-Institut, Jena.
The fellows will:
- screen a large number of genes by comparing pooled blood samples of patients with sepsis
-use selected genes to produce a micro-array (lst generation) and apply this to individual samples of single patients
- analyze these individual expression data in order to optimize the arrays (2nd generation chips ) and to derive rules for an early recognition of those infected patients developing sepsis and for a prognosis inpatients with severe sepsis/septic shock - evaluate these rules in terms of sensitivity and specificity in additional samples; (development of "final" chip and adapted software)
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences software
- medical and health sciences clinical medicine critical care medicine
- social sciences sociology social issues social inequalities
- medical and health sciences clinical medicine anaesthesiology
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
07745 JENA
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.