Developing tumor vaccines, that utilise bodies own immune system, through dc targeting.

Project Information

DC-TARGETING

Grant agreement ID: HPMI-CT-2002-00217

Project closed

Start date 1 August 2002

End date 31 July 2006

Funded under

• Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002)

Total cost € 111 000,00

EU contribution € 111 000,00

Coordinated by

CRUCELL HOLLAND B.V.
Netherlands

Objective

Ways being explored to use the human immune system to generate enhanced immune responses (therapeutic vaccination) against non-infectious diseases like cancer and diabetes. Dendritic cells are the key players in the initiation of the immune response. For Dendritic Cells to become successful in tumor vaccination, various improvements are required, including the quality of the Dendritic Cells. Crucell Holland BV believes this can only be achieved by targeting to natural occurring Dendritic Cells in vivo. The research area involves the triggering of Dendritic Cells in the right context for differentiation and maturation so the Dendritic Cells can optimally mount immune responses. Monoclonal antibodies are excellent candidates that can serve as such a targeting vehicle. Crucell has used a phage antibody display technology and the proprietary MAbstract technology with blood, tonsil, synovial fluid and monocyte derived Dendritic Cells to obtain a large panel of monoclonal antibodies in vivo or Dendric Cells and monocytes which the aim of using these as a targeting vehicle to deliver tumor associated antigens to in vivo Dendritic Cells. The studies carried out within this research project should provide a major step forward in developing a tumor vaccine that utilizes the body's own immune system to combat various types of cancer.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › basic medicine › immunology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• medical and health sciences › clinical medicine › oncology

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Programme(s)

• FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002)

Topic(s)

Data not available

Call for proposal

Data not available

Funding Scheme

BUR - Bursaries, grants, fellowships

Coordinator

CRUCELL HOLLAND B.V.

• EU contribution: No data
• Address: Archimedesweg 4 ; 2301 CA LEIDEN ; Netherlands
• Total cost: No data