Objective
The Department of Human Genetics, University of Leuven, invites applications for post-graduate fellowships (6-12 months) for research training in the molecular pathology and cell biology of neurodegeneration and malignancy. The Research Department consists of 5 research groups sharing important infrastructure and equipment. Collaborative programs combining the specific expertises of the different groups are strongly encouraged. The Department is also part of the Flanders Interuniversity Institute for Biotechnology. Candidates should have a background in molecular genetics, developmental genetics or cell biology. The group for Glycobiology and Developmental Genetics is studying the role of cell surface proteoglycans of the syndecan and glypican families in signal transduction in (neuronal) development. These molecules are the major source of heparan sulfate at the cell surface, bind ligands (FGFs, Wnts, HGF, VEGF, ...) to the cell surface and enhance their interaction with signaling receptors. Heparanases, add an important dimension of regulation to theses systems. The working hypothesis and research strategy of the Neuronal Cell Biology group supposes a common pathogenic pathway in all the forms of Alzheimer disease: the abnormal proteolysis of APP. Projects aims at the understanding of the function of APP, the presenilins, the secretases and at the identification of additional proteins operating in this network. Two groups address the molecular oncology of solid tumors, leukemias and lymphomas. By discovering consistent tumor-specific lesions of the HMGIC,HMGI(Y), LPP, PLAG1, ETV6, API2 and MLT genes and various modes of implication of these genes in the tumoral process, the department established connections with basic signaling pathways. Emphasis is on normal and aberrant cell biology of the different genes. A core facility for transgenesis supports the development of animal models within this framework.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine pathology
- medical and health sciences clinical medicine oncology leukemia
- medical and health sciences basic medicine medical genetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3000 LOUVAIN / LEUVEN
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.