The D-LAB program aims to develop, produce and evaluate systems and protocols for the D/2H-labelling of biological macromolecules that will extend and enhance their structural and dynamical analysis at neutron scattering and NMR LSF throughout Europe. Specific objectives of D-LAB are to:
- Exploit developments at the central Deuteration Laboratory in Grenoble to enable more efficient production of specifically H/D-labelled cells, proteins, nucleic acids and other bio-molecules;
- Develop more efficient methods to produce deuterium labelled biological macromolecules that will benefit the European biological community;
- Evaluate and exploit these methods and reagents in improvement of downstream technology, including data collection and interpretation for neutron scattering and NMR;
- Train young scientists in these techniques. The tools and facilities produced will allow for higher throughput of experiments than are currently performed and will provide new, more sophisticated approaches to the solution of complex biological problems. The list of deliverables is considerable and includes new protocols and techniques for the production of H/D-labelled biological macromolecules and improved methods for analysis.
Funding SchemeCSC - Cost-sharing contracts
OX1 3QU Oxford