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Adaptation to changing nutritional environments: stress and growth regulation in yeasts, plants and plant-pathogenic fungi

Objective

Globally, a large fraction of crops are subjected to fungal diseases leading to great economic losses. Antifungal chemicals currently used are harmful to the environment and therefore due to be replaced in the future. Finding alternatives will depend on molecular understanding of the biology of pathogen colonization of plants with the aim of developing radically new environmentally safe methods of pathogen control. ACE should significantly contribute to research into mechanisms of plant -pathogen interactions and to developing new strategies for pathogen control. The consortium of the ACE research groups combines the expertise in pathways necessary for the transfer of external signals in yeasts, plants, and fungal plant pathogens. Since there is evidence that signal pathways crucial in plant-pathogen interactions are related to yeast pathways, expertise of participant groups on yeast nutritional and stress signal transduction pathways will guide the search for pathways in pathogens and host plants. ACE research groups already successfully studying plant-fungal pathogen interactions will help our network to gain a molecular understanding of signalling pathways involved. Using the most modern genetic and molecular biological technology currently available, e.g. expression profiles of various fungal plant pathogens will provide useful information on fungal adaptation strategies in their host plants. Some of the genes induced by plant-pathogen interactions could encode pathogenicity factors. By studying genome expression and proteomes of the interacting organisms, signal perception, transduction and target factors will be defined that can be genetically modified and knocked out. The mutant phenotypes thus created will allow to draw conclusions on the roles of proteins as pathogenicity factors and will define future targets for the protection of crop plants in agriculture.

Funding Scheme

NET - Research network contracts

Coordinator

INSTITUTE FOR BIOCHEMISTRY AND MOLECULAR CELLBIOLOGY
Address
Dr. Bohrgasse 9
1030 Wien
Austria

Participants (6)

COMMISSARIAT A L'ENERGIE ATOMIQUE
France
Address
Cea / Caclay Bat 532
91191 Gif Sur Yvette
Christie Hospital NHS Trust
United Kingdom
Address
Wilmslow Road Didsbury
M20 9BX Manchester
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Karl-von-frisch Strasse
35043 Marburg
UNIVERSITAET BASEL
Switzerland
Address
70,Klingelbergstrasse 70
4056 Basel
WAGENINGEN UNIVERSITY
Netherlands
Address
Arboretumlaan 4
6703 BD Wageningen
WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Herzl Street 2
76100 Rehovot