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Excitation-contraction coupling and calcium signalling in health and disease

Objective

In skeletal and heart muscle, the signal transduction between the cell surface membrane and the contractile apparatus, called excitation-contraction coupling (ECC), is a model for calcium flux and homeostasis of unique importance. No other organs respond so dramatically to their use or inactivity by hypertrophy or atrophy. Our aim is to study the regulation and molecular basis of ECC in health and disease in man and in animal and cell models.
Our goals are:
a) to identify novel ECC proteins and characterize their interaction at the molecular level;
b) to study localization and targeting of the proteins to their respective compartments, and their interaction using cellular and animal and disease models;
c ) to functionally analyze ECC and calcium signaling with high-resolution imaging and electrophysiological techniques;
d) to study the genetics and pathophysiology of disease arising from EEC defects. Our proposal integrates a large number of state-of -the-art technologies in the fields of protein biochemistry, molecular genetics, cell biology and physiology.

Funding Scheme

NET - Research network contracts

Coordinator

UNIVERSITY OF ULM
Address
Albert-einstein-alle, 11
89069 Ulm
Germany

Participants (7)

LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK
Austria
Address
3,Fritz-pregl-strasse 3
6020 Innsbruck
NATIONAL UNIVERSITY OF IRELAND - MAYNOOTH
Ireland
Address

47 Maynooth - Co. Kildare
UNIVERSITA DEGLI STUDI DI FERRARA
Italy
Address
Via Luigi Borsari, 46
44100 Ferrara
UNIVERSITA' DEGLI STUDI DI SIENA
Italy
Address
Via Banchi Di Sotto 55
Siena
UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
Address
Lee Maltings, Prospect Row
30 Cork
UNIVERSITY OF BERNE
Switzerland
Address
5,Buehlplatz 5
3012 Bern
UNIVERSITY OF DEBRECEN
Hungary
Address
Nagyerdei Krt. 98
4012 Debrecen