Objective
Foreseen Results
With the aim of assessing the significance of worker exposure to heavy metals in the countries of Central Europe (CCE), and to improve the scientific basis for defining occupational standards, the submitted project focuses on two critical areas :
evaluation of genotoxic effects per se,
assessment of the extent to which some heavy metal ions may potentiate the low-dose effects of other carcinogens and mutagens by interference with the DNA-processing machinery, e.g. replication, recombination and repair.
To explore these aspects of metal toxicity, the proposal includes :
direct investigation of genotoxic endpoints in exposed human populations including measurements of DNA-adduct levels and,
features the use of DNA-technology in combination with an experimental assessment of a variety of genetic endpoints in vitro and in vivo under controlled exposure conditions.
In the regulatory context, a distinction between genotoxic and non-genotixic (epigenetic) modes of action constitutes an important element to be considered in quantitative risk assessment of carcinogens as well as in classification for the purpose of labeling. This project will provide such information with respect to selected heavy metals, for which the mechanism of carcinogenic actions is not known, and that present a significant occupational hazard within CCE as well as in certain EU countries. The operation of synergetics effects have been an often articulated serious concern with respect to mixed exposures. An opportunity will be provided to assess the importance of such interactions with respect to heavy metals and cancer initiators in human populations.
Genotoxicity is relevant with respect to occupational cancer as well as adverse effects on reproduction and fetal development, and analysis of chromosomal aberrations in peripheral lymphocytes have been successfully used for quantitation of dose several years after radiation accidents. Any potentiation of DNA-damage caused by the presence of metal ions will have to be considered in the risk evaluation of mixed exposures.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine obstetrics fetal medicine
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
106 91 Stockholm
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.