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Health risk for the general and working population associated with non ferrous smelters activities in eastern Europe: an assessment based on biomarkers of internal dose and early non genotoxic effects

Objective


Foreseen Results

The objectives of this proposal are :

the assessment of health risks linked to indoor and outdoor pollution by non-ferrous smelters activities in Eastern Europe;
the development and validation of biomarkers that have a sufficient toxicological relevance to be used for health risk assessment
Protocol :

Smelters : 2 non-ferrous smelters will be examined : one in Poland and the other in Czech Republic
Populations to be examined : occupationally exposed and controlled adults and children living around the smelters (and controls)
For each smelter it is planned to examine 300 subjects (total 600) inclosing 50 exposed and 50 control workers; 50 boys and 50 girls exposed, 50 boys and 50 girls as controls
Environmental data : the following data will be available to evaluate the pollution : data from classical monitoring of air pollutants (SO2, dusts), determination of Pb, Cd, Hg, An, As in atmosphere and in dustfalls (on soils and playgrounds of schools)
Questionnaire : personal history, smoking habits, respiratory symptoms, leisure activities, drug consumption and other confounders
Collection of biological specimens (urines, whole blood, serum)
Standardized spirometry
Data analysis : multiregression analysis to assess the influence of pollutants after adjustment for potential confounders first to compare the populations of the 2 countries and secondly to evaluate the dose-response relationships after gathering these populations.

The project will also develop of the research potency of the associated teams and allow the access to the European training programs in industrial and environmental toxicology.

Coordinator

Universite de Lille II
Address
Place De Verdun
59045 Lille
France

Participants (4)

National Institute of Public Health
Czechia
Address
48,Srobarova
100 42 Praha 10
The Nofer Institute of Occupational Medicine
Poland
Address
8,Teresy Street
90 950 Lodz
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Address
30,Clos Chapelle-aux-champs 30
1200 Bruxelles
UNIVERSITÀ DEGLI STUDI DI PARMA
Italy
Address
Via Gramsci 14
43100 Parma