The objectives of this proposal are :
the assessment of health risks linked to indoor and outdoor pollution by non-ferrous smelters activities in Eastern Europe;
the development and validation of biomarkers that have a sufficient toxicological relevance to be used for health risk assessment
Smelters : 2 non-ferrous smelters will be examined : one in Poland and the other in Czech Republic
Populations to be examined : occupationally exposed and controlled adults and children living around the smelters (and controls)
For each smelter it is planned to examine 300 subjects (total 600) inclosing 50 exposed and 50 control workers; 50 boys and 50 girls exposed, 50 boys and 50 girls as controls
Environmental data : the following data will be available to evaluate the pollution : data from classical monitoring of air pollutants (SO2, dusts), determination of Pb, Cd, Hg, An, As in atmosphere and in dustfalls (on soils and playgrounds of schools)
Questionnaire : personal history, smoking habits, respiratory symptoms, leisure activities, drug consumption and other confounders
Collection of biological specimens (urines, whole blood, serum)
Data analysis : multiregression analysis to assess the influence of pollutants after adjustment for potential confounders first to compare the populations of the 2 countries and secondly to evaluate the dose-response relationships after gathering these populations.
The project will also develop of the research potency of the associated teams and allow the access to the European training programs in industrial and environmental toxicology.
Funding SchemeCSC - Cost-sharing contracts
100 42 Praha 10
90 950 Lodz