Objective
Foreseen Results
This proposal assembles a combination of biochemical, immunological, molecular and genetic approaches to elucidate the plant response to Erwinia using potato as a model. The natural resistance of wild potato species and their hybrids with cultivated potato will provide a model to distinguish the defense genes and proteins associated with resistance to this pathogen. Definition of a category of relevant target genes will allow the use of the powerful transgenic-based approaches to obtain a set of signal transduction mutants and consequently clone the corresponding genes encoding regulatory proteins controlling plant defense responses. These mutants will define essential components in plant defense which can be subsequently utilized for engineering disease resistance. The proposed studies are likely to identify new disease resistance strategies for example by overexpressing signal components or relevant target genes in transgenic crop plants. The nonspecific nature of plant-Erwinia interaction suggests that resistance strategies developed to control this pathogen are likely to be effective against a broad range of different plant pathogens.
Molecular breeding for disease resistance is likely to be the most effective way to generate disease resistant crop plants. Manipulation of the target genes implicated in induced resistance to pathogens or the signal transduction pathways controlling expression of such defense-related genes provide the most promising targets for development of this new generation of resistance strategies. Realization of these strategies will, however require a considerable investment in basic research on the molecular mechanisms of plant-pathogen interaction, characterization of signals and signal transduction pathways involved that lead to a specific defense response. This proposal will systematically address these questions by dissecting a signal transduction pathway leading to induced defense response to a nonspecific bacterial pathogen Erwinia carotovora. Erwinia, the causative agent of soft-rot disease provides an excellent model for such studies due to the extensive knowledge accumulated on the pathology, biochemistry and molecular genetics of this pathogen. The nonspecific nature of the Erwinia-plant interaction allows a detailed study of the basic induced defense responses in plants without the added complication of race-cultivar specific interactions. This proposal will examine the nature of plant defense-related target genes triggered by Erwinia infection or by elicitors produced by this pathogen, characterize components involved in the signal pathways that control expression of these genes and elucidate the molecular interactions that lead to recognition of this pathogen by the plant host. Modulation of defense gene activity by Erwinia or triggering of virulence genes by the host will also be essential components in understanding this interaction.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences molecular biology molecular genetics
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pathology
- agricultural sciences agriculture, forestry, and fisheries agriculture
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00014 Helsinki
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.