Objective
* Study the effect of cell line vaccination on the epidemiology of tropical theileriosis.
* Investigate the mechanisms underlying clinical reactions to macroschizont-infected cell lines.
* Improve vaccine production and diagnostic tests based on macroschizont antigens; develop a test for protective immunity.
* Characterise and isolate the antigens on macroschizont infected cells involved in the generation of immunity and pathogenesis.
* Evaluate diagnostic reagents developed by CT95009 in epidemiological studies in Tunisia and Turkey.
Expected Outcome
* Defining whether cell line vaccination has any effect on the epidemiology of theileriosis.
* Development of methods for producing cell line vaccines without attenuation which are safe and effective.
* Understanding of the mechanisms by which macroschizont-infected cells and macroschizont antigens induce immunity and pathology and cell line vaccines induce protection.
* Identification of potential macroschizont antigens for inclusion in subunit vaccines and antigens involved in pathological immune responses which should be excluded.
* Validate new diagnostic techniques for theileriosis for both sensitivity and specificity.
* Monitor the efficacy of cell line vaccination in Turkey & Tunisia.
* Select and validate diagnostic tests and assess their specificity. In particular study cross reactions between T.annulata and T.hirci/lestoquardi.
* Study the cytokine production of potential vaccine cell lines and their correlation with pathology.
* Study the role of cytokines and antigen EU 106 in the production of attenuated cell line vaccines without prolonged culture.
* Isolate and sequence parasite derived peptides expressed by infected cells and identify which are recognised by cytotoxic T cells from immune animals.
* Identify the role of MHC polymorphism and T cell receptor repertoire in protective and pathogenic CD4 T cell responses to T.annulata.
* Characterise and isolate novel antigens found on macroschizonts and the surface of infected cells. Study their roles in protective immunity.
* Assess immunoreactivity of macroschizont antigens with cells from naturally infected or vaccinated cattle.
* Evaluate diagnostic reagents produced by this project and CT95009
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health epidemiology
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pathology
- agricultural sciences animal and dairy science domestic animals animal husbandry
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH25 9RG ROSLIN
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.