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Novel approaches to the epidemiology of resistance to drugs used in the control of bovine trypanosomiasis in east Africa


The main objectives are as follows:
* Assessment the extent and significance of resistance to trypanocidal drugs in selected areas of East and Southern Africa.
* Elucidation of the relationship between existing trypanocidal drug use in cattle, both prophylactic and therapeutic, and the development, extent and significance of resistance to trypanocidal drugs.
* Investigation of the importance of trypanocidal drug resistance and implications thereof for the efficacy of trypanocidal use, both prophylactic and therapeutic.
* Provision of a rational basis for sound use of prophylactic and therapeutic drugs in the control of bovine trypanosomiasis, with a view to minimizing the development and spread of trypanocidal drug resistance.
* Provision of National Agricultural Research Systems (NARS) with techniques which will enable them to make recommendations to national and regional tsetse and trypanosomiasis control programmes for the improvement of trypanosomiasis control strategies.
* Contribution to the development of a simple test for diagnosis of drug-resistant trypanosome infections and to the international standardisation of trypanocidal drug resistance testing.
Expected Outcome

The proposed project activities will result in the provision of appropriate technologies for evaluating the importance of drug-resistance in the control of bovine trypanosomiasis and for studying its epidemiology on a larger scale than has been possible in the past. The proposed work involves the transfer of the latest novel techniques for the investigation of trypanocidal drug resistance from the EU and international institutes in which they were developed, to the African DC institutes which are faced with the task of investigating and controlling the problem of tsetse-transmitted bovine trypanosomiasis.
The key activities are :
* Field activities
* Selection of study sites.
* Field methods of trypanosome infections.
* Obtaining samples from cattle in the field.
* Obtaining background epidemiological data of cattle in the field.
* Laboratory activities
* Implementation of methods of identifying trypanocidal drug resistance.
* Validation of the new Ag-ELISA.
* Diagnosis of trypanosome infections by Ag-ELISA.
* Training of national counterpart staff
* Data analysis
* Creation and maintenance of personal computer databases.
* Demonstration of drug resistance in trypanosomes.
* Calculation of the prevalence of drug resistant trypanosomes.
* Design of improved trypanosomiasis control strategies based on the prevalence of drug resistant trypanosomes.
* Provision of recommendations
* Recommendations to the National and Regional Tsetse and Trypanosomiasis Control Programmes for the improvement of trypanosomiasis control strategies.
* Workshop
* Dissemination of results and recommendations.
* Recommendations for the international standardization of trypanocidal drug resistance testing.

Funding Scheme

CSC - Cost-sharing contracts


University of Glasgow
Bearsden Road
G61 1QH Glasgow
United Kingdom

Participants (6)

Animal Diseases Research Institute, Dar Es Salaam

50 Dar Es Salaam
Central Veterinary Research Institute
10101 Lusaka
Naivasha Road
00503 Kabete
Instituut voor Tropische Geneeskunde Prins Leopold
2000 Antwerpen
International Atomic Energy Agency
5,Wagramerstrasse 5
2444 Seibersdorf
Kenya Trypanosomiasis Research Institute

124 Kikuyu