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A comprehensive multidisciplinary study on the natural history of hiv- infection, the pathogenic properties of different hiv-1 genotypes and their role in the epidemiology of hiv in Tanzania and Uganda

Objective

* Retrospective study (1988-1995) to determine the different subtypes present in the regions, to identify their geographical distribution and possible alterations of the proportions in different population groups over the observation period.

* Consistency check, whether the current distribution of subtypes in AIDS patients in a specific region is comparable to the distribution of subtypes in this region seven years ago (at the approximate time of infection.)
Expected Outcome

* The distribution of subtypes in different geographical regions and in different population groups.
* A probable change of predominance of subtypes over the years, which gives an insight into differences in transmission efficacy.
* Detection of new strains from other parts of Africa to the Mbeya Region.
* Detection of new variants.
* Essential information for the preparation of vaccine campaigns in this region
* Differences between the distribution of subtypes at the time of conversion (5-7 years ago) and the present distribution. This could reveal possible differences in pathogenicity in the different strains.
* 1.200 Tanzanian and 900 Ugandan serum samples are tested by V3-serotyping ELISA by the African partners.
* 10% of the samples will be reanalysed as control group by LMU by V3-serotyping ELISA.
* Approx. 20% of the 2100 samples will be untypable by V3-loop ELISA. These will be referred to Europe and will by analysed by HMA (SMH) and sequencing (LMU).
* Consistency check whether the subtype distribution of 100 AIDS patients of the year 1995 is comparable with the distribution of 100 AIDS of the year.

Call for proposal

Data not available

Coordinator

Ludwig-Maximilians-Universität München
Address
Leopoldstraße 5
80802 München
Germany

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Participants (3)

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Norfolk Place - St Mary's Hospital
W2 1PG London

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Ministry of Health of Tanzania
Tanzania
Address

Mbeya

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Ministry of Health of Uganda
Uganda
Address

Fort Portal

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