Objective
* Retrospective study (1988-1995) to determine the different subtypes present in the regions, to identify their geographical distribution and possible alterations of the proportions in different population groups over the observation period.
* Consistency check, whether the current distribution of subtypes in AIDS patients in a specific region is comparable to the distribution of subtypes in this region seven years ago (at the approximate time of infection.)
Expected Outcome
* The distribution of subtypes in different geographical regions and in different population groups.
* A probable change of predominance of subtypes over the years, which gives an insight into differences in transmission efficacy.
* Detection of new strains from other parts of Africa to the Mbeya Region.
* Detection of new variants.
* Essential information for the preparation of vaccine campaigns in this region
* Differences between the distribution of subtypes at the time of conversion (5-7 years ago) and the present distribution. This could reveal possible differences in pathogenicity in the different strains.
* 1.200 Tanzanian and 900 Ugandan serum samples are tested by V3-serotyping ELISA by the African partners.
* 10% of the samples will be reanalysed as control group by LMU by V3-serotyping ELISA.
* Approx. 20% of the 2100 samples will be untypable by V3-loop ELISA. These will be referred to Europe and will by analysed by HMA (SMH) and sequencing (LMU).
* Consistency check whether the subtype distribution of 100 AIDS patients of the year 1995 is comparable with the distribution of 100 AIDS of the year.
Fields of science
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
80802 München
Germany