Objective
* To seek a better prognosis for BL, based on clinical re-evaluation and reassessment of treatment, particularly for patients with non-responsive tumors, correlating patient data with molecular exploration of tumor tissue, and/or sera or whole blood analyses.
* To establish new assays for diagnosis, some of which will be designed for use on site in Malawi, and analyzing viral (and cellular) gene expression, correlating data with clinical information.
* To generate useful questionnaires regarding patient and family histories, as they may relate to onset of the disease, or the different individual clinical patterns observed, looking for possible genetic and/or environmental links to disease.
* To explore viral markers that may have bearing on treatment of disease, aimed at correlation with clinical behavior. To build up a profile of EBV gene expression alongside patients data.
* To train local personnel to help in management of the BL programme, both with regard to data collection, analysis, patient management and laboratory work.
Expected Outcome
* Data that lead to the re-evaluation of BL, and improved methodologies for correlating gene expression with patient prognosis.
* New assays relevant to diagnosis and treatment of BL, and an overall better understanding of this major childhood tumor in sub-Saharan Africa.
* Trained local personnel to work on BL projects in longer term.
* Distribution of findings to other African countries where BL is a major childhood tumor, and publication of data as a means of distributing information further afield.
* To establish an effective communications system among the partners, both with regard to exchange of data and of materials.
* To train local personnel with respect to sample and data collection and interpretation, also with regard to laboratory diagnoses.
* To set up serum, blood and tissue banks on patients, and suitable controls, for assaying with regard to EB viral (and cellular) gene expression.
* To re-evaluate treatment protocols, particularly with regard to patients with tumors that do not respond to conventional chemotherapy, hunting for patterns between EB viral gene expression and tumor response.
* To explore the establishment of BL in an animal model to provide continuing sources of tumor material for analyzing gene expression within a single tumor population; alternatively, using molecular approaches to generate gene expression libraries for evaluation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- humanitieshistory and archaeologyhistory
- natural sciencesbiological sciencesmicrobiologyvirology
- engineering and technologymedical engineeringmedical laboratory technologylaboratory samples analysis
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
LONDON
United Kingdom