Objective
To obtain increased knowledge in humans about:
* Dose-response relationship between cadmium exposure and kidney dysfunction
* Bone effects of cadmium (Cd) and its relationship to kidney dysfunction
* Adverse effects of Cd on male reproduction
* Preventive measures against the adverse human health effects of cadmium
Expected Outcome
The studies will generate new and important knowledge about the dose-response relationships for kidney dysfunction using both well established and newly developed bioindicators. It will demonstrate effects of Cd exposure on bone density in an area outside of Japan. Such information will be of crucial importance in risk assessments for cadmium since the occurrence of bone effects outside of the original Japanese areas where itai-itai diseases occurred is much debated. Since effects of Cd on male reproductive function has been extensively documented in animals , it will be of great value to obtain information in humans concerning the absence or occurrence of such effects in a Cd exposed group of male persons. Data obtained can be directly used for preventive action by Chinese Health Authorities participating in studies.
Population groups with high and medium Cd exposure via rice will be compared with controls concerning: measured Cd concentration in urine (indicator of cumulative exposure), indices of kidney dysfunction (urinary beta-2-microglobulin, albumin and other protein). Bone density will be measured in selected population groups by external measurements and biomarker of bone effects will be analysed in blood samples from the same groups. Male persons will be invited to join a sex function test (assessment of semen quality and sexual hormones in serum). The same measurements will be performed also on a group of persons from the selected areas, who have or have had occupational Cd exposure at the smelter.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine andrology
- medical and health sciences health sciences public health epidemiology
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences earth and related environmental sciences environmental sciences pollution
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
901 87 Umee
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.