Objective
The final goal of the project is to characterize and optimize the in vitro interactions of a small networks of neurons, coupled to an array of embedded stimulating / recording planar microelectrodes, with other neuron populations, spatially separated from the network, simulating a host neural tissue to be interfaced to the network. In other words: the goal is to simulate in vitro the fate of a hybrid neuro - electronic system grafted into an injured nervous system, to stimulate its recovery.
The in vitro characterization and optimization studies will be carried out inside a newly designed micromachined multicompartment chamber (NESTING chamber) which will be fabricated by means of advanced glass and silicon technologies. This chamber will allow a coordinated extensive analysis at the cellular and molecular level of chemical, mechanical and electrophysiological factors influencing neuronal growth, guidance and synaptogenesis under controlled in vitro conditions.
Efforts will be specifically directed to build up in vitro neurobiological models sophisticated enough to reproduce some key features of the in vivo environment. Such models should offer a new advanced tool for in vitro experimentation to the Biomedical Community, thus reducing the need for animal experiments.
By the end of the project, it is expected that detailed indications for the design of a miniaturized version of the neuro-electronic system will be obtained, suitable for subsequent in vivo grafting.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- engineering and technology materials engineering amorphous solids
- natural sciences chemical sciences inorganic chemistry metalloids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
16145 Genova
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.