Objective
Coeliac disease (CD) is a permanent intolerance for proteins of grains (wheat, rye, barley and possibly oats) called gluten, characterized by villous atrophy of the small intestine. The disease is treated with a gluten-free diet. The incidence of diagnosed CD in Europe is about 1: 2000 live births. Typical cases manifest with chronic diarrhoea, weight loss and abdominaldis tension. However, the clinical spectrum of CD is highly heterogeneous and many CD cases present with extra intestinal complaints, such as anaemia, short stature, pubertal delay, osteoporosis or neurological disorders. Sometimes CD is clinically silent. The widespread use of CD screening tests (determination in serum of IgA antigliadin and anti endomysium antibodies) has shown that, in most European countries, the number of CD cases which remain undiagnosed and untreated is, much higher than the number of patients who are correctly diagnosed on clinical ground. A recent Italian multi centre survey on 17,201apparently healthy students showed a prevalence of CD of 1 in 184 subjects, with a ratio of 1:7 recognized versus unrecognised CD cases. These results indicate that in Europe CD is one of the most common lifelong disorders. Persons with CD have malignancies, especially of the gastrointestinal tract, at a significantly higher frequency than the general population: 8.1-13.3% of the patients develop cancer. In CD there is a 43-fold relative risk (RR) for non-Hodgkin small bowel Iymphoma, a 12-fold RR for oesophagus cancer and a10-fold RR for cancer of the mouth and pharynx. A prolonged treatment with a gluten-free diet seems to play a protective role against cancer in these patients. Recent studies suggest that patients with untreated CD are also at high risk of developing non-Hodgkin Iymphoma (NHL) of any primary site. Patients affected by dermatitis herpetiform is, which is considered one of the many clinical forms of CD, are at 5-10 fold risk of developing NHL. While primary intestinal Iymphoma is a rare condition; NHL is one of the most commonneo plastic disorders in Europe. The purpose of this study is to evaluate whether in Europe untreated CD is a primary risk factor to developed NHL at anyprimary site and to quantify the relative risk. The hypothesis is that in Europe untreated (unrecognised. subclinical a symptomatic. neglected) CD is responsible for a heavy burden of preventable malignancies in the general European population. Plan of investigation: Multicentre, European, prospective, case-control study. Cases: persons with NHL at onset identified in defined areas. Controls: patients sex and age-matched to the cases, seen at hospitals for disorders not related to CD. The existence of untreated CD will be investigated in cases and in controls by means of clinical, serological, histological and HLA studies. The hypothesis will be indirectly tested by comparing the prevalence of CD in subjects with NHL and in the controls. Relevance: This study represents a significant step forward on the epidemiological European research to determinate abnormalities which can predispose to cancer. If the prevalence for NHL is significantly increased in untreated CD the identification and treatment of missed cases of CD should become important in the prevention of cancer in Europe and in the improvement of the health of the European population.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences nutrition
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine neurology
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds cereals
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2333 ZA Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.