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Study of genetic and environmental factors in the pathogenesis of the most frequent chromosomal anomalies

Objective

Clinical and genetic examination of profanes and their parents, creation of Donavan, epidemiological case-control study of impact of environmental risk factors in aetiology of developmental disorders due to the most frequent chromosomalaneuploidies in regions of Russia and Ukraine with environmental pollution including Chernobyl radiation exposure. Use of improved 24-colour FISH, micro-Chan rnulticolor PRINS supported by new generation of DNA probes and quantitative fluorescent PCR for rapid and reliable aneuploidy diagnosis in single cells ormicroquantity of cells and for the use in preconceptual, prefertilization, preimplantation, prenatal and postnatal diagnosis , prevention and better care for affected profanes. The ascertainment of the role of environmental risk factors in the aetiology of aneuploidies by analysis of epidemiological data and by determination of parental and meiotic origin of the aneuploidies .

Funding Scheme

CSC - Cost-sharing contracts
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Coordinator

UNIVERSITY HOSPITAL MOTOL
Address
V Uvalu 85
150 06 Praha 5
Czechia

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue De La Cardonille 141
34396 Montpellier
HUMBOLDT-UNIVERSITAET BERLIN
Germany
Address
1,Augustenburger Platz 1
13353 Berlin
INSTITUTE OF CHILD HEALTH
Greece
Address
"Aghia Sophia" Children Hospital
11527 Athens
INSTITUTE OF MEDICAL IMPROVEMENT
Ukraine
Address
Cheshskaya Street 130
254114 Kiev
INSTITUTE OF PEDIATRICS AND CHILDREN SURGERY - MINISTRY OF HEALTH
Russia
Address
2,Taldomskaya 2
127412 Moscow
KLINIKUM DER FRIEDRICH-SCHILLER-UNIVERSITAET JENA
Germany
Address
Kollegiengasse 10
07740 Jena
NATIONAL RESEARCH CENTER OF MENTAL HEALTH - RUSSIAN ACADEMY OF MEDICAL SCIENCES
Russia
Address
2,Zagorodnoe Sh 2
113152 Moscow
ROSTOV STATE MEDICAL UNIVERSITY
Russia
Address
Nachitchevansky Pereulok 29
344022 Rostov On Don
UNIVERSITY OF LUEBECK
Germany
Address
Ratzeburger Allee 160
23538 Luebeck