Clinical and genetic examination of profanes and their parents, creation of Donavan, epidemiological case-control study of impact of environmental risk factors in aetiology of developmental disorders due to the most frequent chromosomalaneuploidies in regions of Russia and Ukraine with environmental pollution including Chernobyl radiation exposure. Use of improved 24-colour FISH, micro-Chan rnulticolor PRINS supported by new generation of DNA probes and quantitative fluorescent PCR for rapid and reliable aneuploidy diagnosis in single cells ormicroquantity of cells and for the use in preconceptual, prefertilization, preimplantation, prenatal and postnatal diagnosis , prevention and better care for affected profanes. The ascertainment of the role of environmental risk factors in the aetiology of aneuploidies by analysis of epidemiological data and by determination of parental and meiotic origin of the aneuploidies .
Funding SchemeCSC - Cost-sharing contracts
344022 Rostov On Don