Objective
The purpose of the research is to elucidate immune mechanisms and specificities that correlate with parasitological protection in three complementary systems: i) the target system of Onchocerca ovules in humans ii) the closely analogous system of Onchocerca change in cattle (which permits experimental manipulation in laboratory and field settings); iii) in the mouse model of Litosomoides sigmodontis (which permits detailed immunological analysis in a host supporting complete development of a filarial nematode.) In combination, these systems allow us to address the basis of naturally acquired immunity (against developing larvae and/or microfilariae) through immunoepidemiological and case-controlled comparisons (using defined antigens and parasite extracts); the basis of vaccine-induced immunity (using defined antigens and irradiated larvae); the impact of chemotherapy (both adulticides and microfilaricides ) on protection; and the effects of immunomodulation mediated by chronic infection.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH25 9RG ROSLIN
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.