Objective
In the context of treatment/reinfection studies in fishing communities on Lake Albert, Uganda, the objectives of this proposal are to identify and characterise:Cellular immune and serological correlates of human immunity to schistosomiasis in a high transmission area where reduced adult exposure to infection does not confound age-dependent immunity.[b] parasite antigens that are targets for immune responses that correlate with immunity, with emphasis on IgE inducing recombinant tegumental Ags.[c] human responses against tegument/tegument-secreted molecules that are vital for parasite physiology and thus constitute rational targets for vaccine immunity.[d]Th2-cytokine mediated effectors mechanisms which correlate with human immunity and factors controlling their expression.[e]immunomodulating effect of anti-schistosome chemotherapy, in relation to introduction of protective human responses and potential effect on anti-schistosome vaccination.
Fields of science
Topic(s)
Data not availableCall for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
Participants (7)
2920 Charlottenlund
See on map
Nairobi
See on map
2 Nairobi
See on map
Kampala
See on map
CB3 7PX Cambridge
See on map
2100 Koepenhagen
See on map
LS2 9JT Leeds
See on map