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Human immunity to schistosomiasis: antigens, mechanisms and the influence of treatment.

Objective

In the context of treatment/reinfection studies in fishing communities on Lake Albert, Uganda, the objectives of this proposal are to identify and characterise:Cellular immune and serological correlates of human immunity to schistosomiasis in a high transmission area where reduced adult exposure to infection does not confound age-dependent immunity.[b] parasite antigens that are targets for immune responses that correlate with immunity, with emphasis on IgE inducing recombinant tegumental Ags.[c] human responses against tegument/tegument-secreted molecules that are vital for parasite physiology and thus constitute rational targets for vaccine immunity.[d]Th2-cytokine mediated effectors mechanisms which correlate with human immunity and factors controlling their expression.[e]immunomodulating effect of anti-schistosome chemotherapy, in relation to introduction of protective human responses and potential effect on anti-schistosome vaccination.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (7)

DANISH BILHARZIASIS LABORATORY
Denmark
Address
1D,jaegersborg Allee 1D
2920 Charlottenlund
KENYA MEDICAL RESEARCH INSTITUTE
Kenya
Address
Mbaghati Road
Nairobi
MINISTRY OF HEALTH
Kenya
Address

2 Nairobi
MINISTRY OF HEALTH OF UGANDA
Uganda
Address
15,Bombo Road 15
Kampala
MR. ANTHONY BUTTERWORTH
United Kingdom
Address
The Footpath 47
CB3 7PX Cambridge
THE REFERENCE LABORATORY
Denmark
Address
4,Henrik Harpe Strengs Vej 4
2100 Koepenhagen
UNIVERSITY OF LEEDS
United Kingdom
Address
Woodhouse Lane
LS2 9JT Leeds