Human immunity to schistosomiasis: antigens, mechanisms and the influence of treatment.

Objective

In the context of treatment/reinfection studies in fishing communities on Lake Albert, Uganda, the objectives of this proposal are to identify and characterise:Cellular immune and serological correlates of human immunity to schistosomiasis in a high transmission area where reduced adult exposure to infection does not confound age-dependent immunity.[b] parasite antigens that are targets for immune responses that correlate with immunity, with emphasis on IgE inducing recombinant tegumental Ags.[c] human responses against tegument/tegument-secreted molecules that are vital for parasite physiology and thus constitute rational targets for vaccine immunity.[d]Th2-cytokine mediated effectors mechanisms which correlate with human immunity and factors controlling their expression.[e]immunomodulating effect of anti-schistosome chemotherapy, in relation to introduction of protective human responses and potential effect on anti-schistosome vaccination.

Programme(s)

• FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (7)

DANISH BILHARZIASIS LABORATORY

Denmark

Address

1D,jaegersborg Allee 1D
2920 Charlottenlund

KENYA MEDICAL RESEARCH INSTITUTE

Kenya

Address

Mbaghati Road
Nairobi

MINISTRY OF HEALTH

Kenya

Address

2 Nairobi

MINISTRY OF HEALTH OF UGANDA

Uganda

Address

15,Bombo Road 15
Kampala

MR. ANTHONY BUTTERWORTH

United Kingdom

Address

The Footpath 47
CB3 7PX Cambridge

THE REFERENCE LABORATORY

Denmark

Address

4,Henrik Harpe Strengs Vej 4
2100 Koepenhagen

UNIVERSITY OF LEEDS

United Kingdom

Address

Woodhouse Lane
LS2 9JT Leeds