Objective Malaria vaccines are urgently required. Recombinant multi-component cocktail vaccines are currently favoured. Using very recent technological advances this programme revives the concept of attenuated parasites as vaccines. It bring together for the first leading EU and African groups to develop methodologies allowing the design and creation of parasites with properties desirable in such a vaccine. The ultimate delivery of such a vaccine may be as either sexually incompetent, genetically restricted parasites, or as transmissible self-spreading forms. For either route certain fundamental pre-conditions must be met, and these are the major focus of this proposal; Systems will be developed to provide1) auxotrophic parasites2) sequential unrestricted genetic manipulation of parasites3) axenic culture4) parasite knock outs for specific genes and5) immuno-potentiated parasites through heterologous gene expression. In combination with a dialogue across scientific and public interests this programme will enable the partnership to provide a clear assessment of the feasibility of vaccination with genetically modified malaria within three years. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator LEIDEN UNIVERSITY Address Wassenaarseweg 72 2333 AL Leiden Netherlands See on map EU contribution € 0,00 Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE Netherlands EU contribution € 0,00 Address 151,lange kleiweg 151 2280 GH Rijswijk zh See on map MED BIOTECH LABORATORIES Uganda EU contribution € 0,00 Address Sekindi close plot 3438 - myenga 10 Kampala See on map UNIVERSITAETSKLINIKUM HEIDELBERG Germany EU contribution € 0,00 Address Im neuenheimer feld 324 69120 Heidelberg See on map UNIVERSITY COLLEGE OF IBADAN Nigeria EU contribution € 0,00 Address University college hospital Ibadan See on map
