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New genetic techologies: application to generate attenuated malaria vaccines

Objective

Malaria vaccines are urgently required. Recombinant multi-component cocktail vaccines are currently favoured. Using very recent technological advances this programme revives the concept of attenuated parasites as vaccines. It bring together for the first leading EU and African groups to develop methodologies allowing the design and creation of parasites with properties desirable in such a vaccine. The ultimate delivery of such a vaccine may be as either sexually incompetent, genetically restricted parasites, or as transmissible self-spreading forms. For either route certain fundamental pre-conditions must be met, and these are the major focus of this proposal;
Systems will be developed to provide
1) auxotrophic parasites
2) sequential unrestricted genetic manipulation of parasites
3) axenic culture
4) parasite knock outs for specific genes and
5) immuno-potentiated parasites through heterologous gene expression. In combination with a dialogue across scientific and public interests this programme will enable the partnership to provide a clear assessment of the feasibility of vaccination with genetically modified malaria within three years.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LEIDEN UNIVERSITY
Address
Wassenaarseweg 72
2333 AL Leiden
Netherlands

Participants (4)

FOUNDATION BIOMEDICAL PRIMATE RESEARCH CENTRE
Netherlands
Address
151,Lange Kleiweg 151
2280 GH Rijswijk Zh
MED BIOTECH LABORATORIES
Uganda
Address
Sekindi Close Plot 3438 - Myenga
10 Kampala
UNIVERSITAETSKLINIKUM HEIDELBERG
Germany
Address
Im Neuenheimer Feld 324
69120 Heidelberg
UNIVERSITY COLLEGE OF IBADAN
Nigeria
Address
University College Hospital
Ibadan