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Prevention of hydatidosis by development of an oral vaccine against echinococcus granulosus infection of the dog

Objective

Hydatidosis is a parasitose caused by the larval stage of the Cestod Echinococcus granulosus. It has a worldwide distribution and affects a large number of domestic and wild ungulates, and accidentally, humans. In hyper-endemic areas, particularly in countries of the Maghreb, hydatidosis causes serious economical and public health problems. We propose the development of a vaccine that could protect the dog, host of adult stage of the parasite and thus could interrupt the life cycle of the parasite. Two proteins located in the tegumental region of Echinococcus granulosus and which are potent immunogens during infections in the dog will be expressed as recombinant proteins in genetically modified Salmonellae. They will provide the basis of an orally administered vaccine. The protective potential of these constructions will be determined in hyper endemic areas against 2 strains of the parasite, on laboratory dogs, then on sheepdogs.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITE CLAUDE BERNARD LYON 1
Address
Avenue Rockefeller 8
69373 Lyon
France

Participants (4)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Boulevard Du 11 Novembre 1918, 43
69622 Villeurbanne
ECOLE NATIONALE DE MEDICINE VETERINAIRE
Tunisia
Address

2020 Sidi Thabet
INSTITUT AGRONOMIQUE ET VETERINAIRE HASSAN II
Morocco
Address
10101,Avenue Allal El Fassi, Rabat Institutes
10101 Rabat / Agdal
University of Cambridge
United Kingdom
Address
Madingley Road
CB3 0ES Cambridge