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Prevention of hydatidosis by development of an oral vaccine against echinococcus granulosus infection of the dog


Hydatidosis is a parasitose caused by the larval stage of the Cestod Echinococcus granulosus. It has a worldwide distribution and affects a large number of domestic and wild ungulates, and accidentally, humans. In hyper-endemic areas, particularly in countries of the Maghreb, hydatidosis causes serious economical and public health problems. We propose the development of a vaccine that could protect the dog, host of adult stage of the parasite and thus could interrupt the life cycle of the parasite. Two proteins located in the tegumental region of Echinococcus granulosus and which are potent immunogens during infections in the dog will be expressed as recombinant proteins in genetically modified Salmonellae. They will provide the basis of an orally administered vaccine. The protective potential of these constructions will be determined in hyper endemic areas against 2 strains of the parasite, on laboratory dogs, then on sheepdogs.


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Avenue rockefeller 8
69373 Lyon

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Participants (4)