Objective Hydatidosis is a parasitose caused by the larval stage of the Cestod Echinococcus granulosus. It has a worldwide distribution and affects a large number of domestic and wild ungulates, and accidentally, humans. In hyper-endemic areas, particularly in countries of the Maghreb, hydatidosis causes serious economical and public health problems. We propose the development of a vaccine that could protect the dog, host of adult stage of the parasite and thus could interrupt the life cycle of the parasite. Two proteins located in the tegumental region of Echinococcus granulosus and which are potent immunogens during infections in the dog will be expressed as recombinant proteins in genetically modified Salmonellae. They will provide the basis of an orally administered vaccine. The protective potential of these constructions will be determined in hyper endemic areas against 2 strains of the parasite, on laboratory dogs, then on sheepdogs. Fields of science medical and health scienceshealth sciencespublic healthagricultural sciencesanimal and dairy sciencedomestic animalsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITE CLAUDE BERNARD LYON 1 Address Avenue rockefeller 8 69373 Lyon France See on map EU contribution No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution € 0,00 Address Boulevard du 11 novembre 1918, 43 69622 Villeurbanne See on map Other funding No data ECOLE NATIONALE DE MEDICINE VETERINAIRE Tunisia EU contribution € 0,00 Address 2020 Sidi thabet See on map Other funding No data INSTITUT AGRONOMIQUE ET VETERINAIRE HASSAN II Morocco EU contribution € 0,00 Address 10101,avenue allal el fassi, rabat institutes 10101 Rabat / agdal See on map Other funding No data University of Cambridge United Kingdom EU contribution € 0,00 Address Madingley road CB3 0ES Cambridge See on map Other funding No data
