Objective
Praziquantel is the drug of choice to cure schistosomiasis, a disease affecting 200 million people, but recent field and laboratory studies suggest that prazi-quantel resistant schistosomes have appeared. We propose to carry out parallelstudies in different laboratories to definitely ascertain the existence and the degree of drug resistance both in the schistosomes that have been previously identified as resistant and in new isolates that we shall obtain from different endemic areas. Using a combination of in vivo and in vitro approaches, we aim to produce a reliable laboratory protocol as well as field-applicable diagnostic tests for the diagnosis of praziquantel resistance. The biological fitness and the genetics of resistant parasites will be defined, as these are crucial determinants of their potential to spread in the population. The efficacy of alternative drugs will be determined as a measure to face possible praziquantel failures.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00016 MONTEROTONDO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.