Objective Vaccine candidates are emerging but the time and cost of TB clinical trials prohibits their evaluation. Surrogate markers are needed. Cells from carefully followed up contacts who do or do not develop disease are being studied forcytokine expression by RT-PCR in 3 African centres. VACSIS will add a 4th centre, upgrade technology to real time RT-PCR, and study markers of apoptosis that play a role in immune response regulation in TB. Meanwhile patients TB strains will by typed for polymorphisms in DNA repair genes, and this will be related to disease severity, transmission and immunology Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Topic(s) Data not available Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY COLLEGE LONDON Address Cleveland street 46 W1P 6DB London United Kingdom See on map EU contribution € 0,00 Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all ARMAUER HANSEN RESEARCH INSTITUTE Ethiopia EU contribution € 0,00 Address 1005 2003 Addis abeba See on map INSTITUT PASTEUR France EU contribution € 0,00 Address Rue du docteur roux 25 75724 Paris See on map INSTITUT PASTEUR DE MADAGASCAR Madagascar EU contribution € 0,00 Address 101 Antananarivo See on map STATENS SERUM INSTITUT Denmark EU contribution € 0,00 Address 5,artillerivej 5 2300 Koepenhagen See on map UNIVERSITY OF ZAMBIA Zambia EU contribution € 0,00 Address Great east road campus 10101 Lusaka See on map
