Host-parasite relationship in susceptibility to tuberculosis

Objective

Vaccine candidates are emerging but the time and cost of TB clinical trials prohibits their evaluation. Surrogate markers are needed. Cells from carefully followed up contacts who do or do not develop disease are being studied forcytokine expression by RT-PCR in 3 African centres. VACSIS will add a 4th centre, upgrade technology to real time RT-PCR, and study markers of apoptosis that play a role in immune response regulation in TB. Meanwhile patients TB strains will by typed for polymorphisms in DNA repair genes, and this will be related to disease severity, transmission and immunology

Programme(s)

• FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY COLLEGE LONDON

Address

Cleveland Street 46
W1P 6DB London
United Kingdom

Participants (5)

ARMAUER HANSEN RESEARCH INSTITUTE

Ethiopia

Address

1005
2003 Addis Abeba

INSTITUT PASTEUR

France

Address

Rue Du Docteur Roux 25
75724 Paris

INSTITUT PASTEUR DE MADAGASCAR

Madagascar

Address

101 Antananarivo

STATENS SERUM INSTITUT

Denmark

Address

5,Artillerivej 5
2300 Koepenhagen

UNIVERSITY OF ZAMBIA

Zambia

Address

Great East Road Campus
10101 Lusaka