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Host-parasite relationship in susceptibility to tuberculosis

Objective

Vaccine candidates are emerging but the time and cost of TB clinical trials prohibits their evaluation. Surrogate markers are needed. Cells from carefully followed up contacts who do or do not develop disease are being studied forcytokine expression by RT-PCR in 3 African centres. VACSIS will add a 4th centre, upgrade technology to real time RT-PCR, and study markers of apoptosis that play a role in immune response regulation in TB. Meanwhile patients TB strains will by typed for polymorphisms in DNA repair genes, and this will be related to disease severity, transmission and immunology

Topic(s)

Data not available

Call for proposal

Data not available

Coordinator

UNIVERSITY COLLEGE LONDON
Address
Cleveland street 46
W1P 6DB London
United Kingdom

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EU contribution
€ 0,00

Participants (5)