Skip to main content

Host-parasite relationship in susceptibility to tuberculosis

Objective

Vaccine candidates are emerging but the time and cost of TB clinical trials prohibits their evaluation. Surrogate markers are needed. Cells from carefully followed up contacts who do or do not develop disease are being studied forcytokine expression by RT-PCR in 3 African centres. VACSIS will add a 4th centre, upgrade technology to real time RT-PCR, and study markers of apoptosis that play a role in immune response regulation in TB. Meanwhile patients TB strains will by typed for polymorphisms in DNA repair genes, and this will be related to disease severity, transmission and immunology

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY COLLEGE LONDON
Address
Cleveland Street 46
W1P 6DB London
United Kingdom

Participants (5)

ARMAUER HANSEN RESEARCH INSTITUTE
Ethiopia
Address
1005
2003 Addis Abeba
INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 25
75724 Paris
INSTITUT PASTEUR DE MADAGASCAR
Madagascar
Address

101 Antananarivo
STATENS SERUM INSTITUT
Denmark
Address
5,Artillerivej 5
2300 Koepenhagen
UNIVERSITY OF ZAMBIA
Zambia
Address
Great East Road Campus
10101 Lusaka