The present research proposal seeks to assess the bacteriological and clinical efficacy of an ofloxacin- containing short-course regimen for the treatment of pulmonary TB in comparison with the standard 6 month short-course regimen. It is a muticentre randomised controlled trial that will be conducted jointly in 5 countries in Africa, with the collaboration of 5 European institutions, using a standardised methodology. Surrogate studies of the sterilising activity of the two regimens will be carried out in parallel. This study is expected to provide a relevant assessment of the possibility to reduce further and effectively the duration of treatment of pulmonary TB, with the aim of obtaining good adherence of the patients to treatment and thus increase TB cure rates. In addition, it will contribute to the development of capacities to establish a network of centres aiming at conducting clinical trials in Africa based around sites of excellence for field research.
Funding SchemeCSC - Cost-sharing contracts
2000 Anvers /Antwerpen
SW17 0RE London