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A multicentre randomized control trial of ofloxacine-containing short-course regimen for the treatment of pulmonary tuberculosis

Objective

The present research proposal seeks to assess the bacteriological and clinical efficacy of an ofloxacin- containing short-course regimen for the treatment of pulmonary TB in comparison with the standard 6 month short-course regimen. It is a muticentre randomised controlled trial that will be conducted jointly in 5 countries in Africa, with the collaboration of 5 European institutions, using a standardised methodology. Surrogate studies of the sterilising activity of the two regimens will be carried out in parallel. This study is expected to provide a relevant assessment of the possibility to reduce further and effectively the duration of treatment of pulmonary TB, with the aim of obtaining good adherence of the patients to treatment and thus increase TB cure rates. In addition, it will contribute to the development of capacities to establish a network of centres aiming at conducting clinical trials in Africa based around sites of excellence for field research.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
Address
Route Des Peres Maristes
Dakar
Senegal

Participants (9)

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
France
Address
Boulevard Raymond Poincare 104
92380 Garches
CHU IGNACE DEEN
Guinea
Address

Conakry
INSTITUTE OF TROPICAL MEDICINE PRINCE LEOPOLD
Belgium
Address
Nationalestraat 155
2000 Anvers /Antwerpen
KENYA MEDICAL RESEARCH INSTITUTE
Kenya
Address
Off Hospital Road
Nairobi
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
United Kingdom
Address
Keppel Street
London
PROGRAMME NATIONAL DE LUTTE CONTRE LA TUBERCULOSE
Benin
Address

817 Cotonou
PROGRAMME NATIONAL DE LUTTE CONTRE LA TUBERCULOSE
Senegal
Address
Rue Aime Cesaire
FANN Dakar
SOUTH AFRICAN MEDICAL RESEARCH COUNCIL
South Africa
Address
C/o King George V Hospital, Stanley Copley Drive
4000 Durban
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
Address
Cranmer Terrace, Jenner Wing
SW17 0RE London