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Regulation of the cell cycle and dormancy in mycobacterium tuberculosis

Objective

Tuberculosis remains as one the most important infectious diseases, causing about three million deaths every year. Developing world accounting for majority of the cases. This disease is intimately linked to the pathogenesis of the causative agent, M. tuberculosis. This bacterium can lie quiescent in unidentified sites in the human host for years without producing overt disease and then revive to cause lesions and in many cases progressive tuberculosis. We propose to identify bacterial genes that govern the latency state of the infection of M. tuberculosis and to establish how they affect the cell cycle division. We will seek to clarify the mechanism by which this bacteria shifts down to a dormant state and reverts to active growth again, and to describe morphologically and functionally the persistent M. tuberculosis cell. Association of IS6110 transpositions to dormancy will be assess.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSIDAD AUTONOMA DE MADRID
Address
C/ Arzobispo Morcillo S/n
28029 Madrid
Spain

Participants (6)

CORPORACION CORPOGEN
Colombia
Address
Carrera 5 N 66-88
Bogota
ESCUELA NACIONAL DE CIENCIAS BIOLOGICAS
Mexico
Address
Prolongacion De Carpio Y Plan De Ayala
11340 Mexico D.f.
INSTITUTO NACIONAL DE LA NUTRICION SALVADOR ZUBIRAN
Mexico
Address
Calle Vasco De Quiroga 15
14000 Tlalpan
INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS
Venezuela
Address
Carreterra Panamericana Km11, Altos De Pipe
1010A Caracas
UNIVERSIDAD DE ZARAGOZA
Spain
Address
S/n,domingo Miral S/n
50009 Zaragoza
UNIVERSITY OF SURREY
United Kingdom
Address

Guildford