Regulation of the cell cycle and dormancy in mycobacterium tuberculosis

Objective

Tuberculosis remains as one the most important infectious diseases, causing about three million deaths every year. Developing world accounting for majority of the cases. This disease is intimately linked to the pathogenesis of the causative agent, M. tuberculosis. This bacterium can lie quiescent in unidentified sites in the human host for years without producing overt disease and then revive to cause lesions and in many cases progressive tuberculosis. We propose to identify bacterial genes that govern the latency state of the infection of M. tuberculosis and to establish how they affect the cell cycle division. We will seek to clarify the mechanism by which this bacteria shifts down to a dormant state and reverts to active growth again, and to describe morphologically and functionally the persistent M. tuberculosis cell. Association of IS6110 transpositions to dormancy will be assess.

Programme(s)

• FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Topic(s)

• 1.2.1.-1.4. - Research for development

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSIDAD AUTONOMA DE MADRID

Address

C/ Arzobispo Morcillo S/n
28029 Madrid
Spain

Participants (6)

CORPORACION CORPOGEN

Colombia

Address

Carrera 5 N 66-88
Bogota

ESCUELA NACIONAL DE CIENCIAS BIOLOGICAS

Mexico

Address

Prolongacion De Carpio Y Plan De Ayala
11340 Mexico D.f.

INSTITUTO NACIONAL DE LA NUTRICION SALVADOR ZUBIRAN

Mexico

Address

Calle Vasco De Quiroga 15
14000 Tlalpan

INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTIFICAS

Venezuela

Address

Carreterra Panamericana Km11, Altos De Pipe
1010A Caracas

UNIVERSIDAD DE ZARAGOZA

Spain

Address

S/n,domingo Miral S/n
50009 Zaragoza

UNIVERSITY OF SURREY

United Kingdom

Address

Guildford