Tuberculosis remains as one the most important infectious diseases, causing about three million deaths every year. Developing world accounting for majority of the cases. This disease is intimately linked to the pathogenesis of the causative agent, M. tuberculosis. This bacterium can lie quiescent in unidentified sites in the human host for years without producing overt disease and then revive to cause lesions and in many cases progressive tuberculosis. We propose to identify bacterial genes that govern the latency state of the infection of M. tuberculosis and to establish how they affect the cell cycle division. We will seek to clarify the mechanism by which this bacteria shifts down to a dormant state and reverts to active growth again, and to describe morphologically and functionally the persistent M. tuberculosis cell. Association of IS6110 transpositions to dormancy will be assess.
Funding SchemeCSC - Cost-sharing contracts
11340 Mexico D.f.