Objective
Respiratory diseases represent a serious threat to health in both the young and old. Viruses and bacteria that cause these diseases enter the body through the mucosal surfaces of the nose, lungs and gastrointestinal tract. A vaccine that provides protection against initial infection would be very advantageous. Classical vaccines are normally administered by injection but they do not provide protection in terms of preventing invasion. In contrast, a mucosal vaccine that is administered to the site(s) of pathogen ingress can provide good long term protection.
Mucosal vaccines achieve this effect by the induction of a secretary antibody (IgA) that interacts and neutralises the invading antigen (pathogen). Moreover, inoculation at one mucosal site can provide protection at other distant mucosal sites through the Common Mucosal Pathway. Mucosal vaccines also have the advantage that they can be easily administered and do not require injection.
As a spin off from a programme on the nasal administration of biotechnology products in the form of peptide and protein drugs, West Pharmaceutical Services has discovered that some of its proprietary nasal delivery systems for drugs could also be appropriate for the delivery of mucosal vaccines. Diphtheria, caused by the organism Corynebacterium diphtheriae was chosen as the target disease. The project aimed to validate the nasal vaccines system before being optimised and scaled up for testing in human trials.
A new non-injectable mucosal vaccine for the prophylaxis of diphtheria cough could have enormous potential in both social and financial terms. The existing diphtheria toxoid vaccine is associated with certain side effects and does not induce mucosal immunoglobulin A (IgA) antibodies to diphtheria that are usually detected following the disease and maybe provide long-lived immunity. A nasal vaccine that induced potent local respiratory response would be advantageous. The fact that it could be administered easily into the nasal cavity of children would be especially advantageous in the developing world where injections are still associated with problems of carrying the risk of spreading infections.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences infectious diseases RNA viruses coronaviruses
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NG7 2TN NOTTINGHAM
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.