Objective
Marburg and Ebola virus make up the family of Filoviridae, which are among the most dangerous viral pathogens. Filoviruses reproduce in the cytoplasm of the infected cell where prominent inclusion bodies are formed which represent stored nucleocapsids. Nucleocapsids undergo several steps of maturation and have then to be transported to the plasma membrane where they are enveloped, and progeny viruses are released into the cultural medium. Hitherto the mechanisms underlying the transport of mature nucleocapsids to the plasma membrane are not understood. Additionally, it is unclear how mature and premature nucleocapsids are discriminated. It is presumed that the cytoskeleton of the infected cells plays an important role in these processes. The proposed project wants to elucidate the importance of acting filaments and microtubules for the transport of filoviral nucleocapsids. This study combines electron microscopical, immuno electron microscopical, molecular biological, and light microscopical analyses to get a detailed picture of nucleocapsid migration and virus morphogenesis. It is expected that gained results lead to a better understanding of the intimate relationship between cellular structures and the viral parasite. Further, these investigations will provide the fundament to develop drugs blocking viral morphogenesis.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
35037 Marburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.