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Content archived on 2022-12-23

Biotechnology, Informatics Oriented Cytochromes Engineering for Novel Structural and Applied Research

Objective

The proposal is focused on several cytochrome P450 systems, which are currently under study by participating teams. Within the network activity teams will perform focused coordinated research, aimed at improvement of methods of expression and purification of recombinant P450s and partner proteins, their structure-functional and enzymatic characterization and 3D structure determination at the atomic level. This assumes regular exchange of information and research achievements (subject to due consideration of Intellectual property rights), collaborative research considering investigation of protein-protein interactions in P450 systems and their ultrastructural studies using the high-resolution techniques (X-ray crystallography, including synchrotron facilities, and scanning probe microscopy). It is anticipated that the proposed research would also lead to identification of new potential targets among cytochrome P450 systems for their practical applications in biosensor design and bioelectronics. The network activity is thought to be achieved also through exchange visits of team members to partner laboratories, performing joint experiments, organization of workshops, conferences. Essential part is devoted to focus interdisciplinary training and education of young scientists in the modern fields of cytochrome P450 bioinfomatics, biotechnology, biosensor technology and nanotechnology.
It is anticipated, that the network will promote and extend the already existing scientific links and lead to new collaborative research projects.

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Programme(s)

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Topic(s)

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Call for proposal

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Funding Scheme

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Coordinator

ELBA foundation
EU contribution
No data
Address
Via delle Testuggini snc
00134 Rome
Italy

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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (5)

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