Objective
All organisms have evolved an intricate network of DNA repair systems that enables them to recognise and eliminate lesions in the DNA induced by the action of numerous chemical and physical agents.
The primary goal of the research of which this joint project is a part is: to unravel the molecular mechanisms, specificity and fidelity of repair of DNA damage in mammalian cells; and elucidate the molecular defects in human genetic disorders associated with DNA repair deficiencies: xeroderma pigmentosum (XP), Cockayne's syndrome (CS), and trichothiodystrophy (TTD), and Progeria (PR), a premature ageing syndrome in which deficient DNA repair might be involved. These diseases are characterised by sun (UV) sensitivity, frequently neurological abnormalities, poor development, for XP predisposition to skin cancer and, in some diseases, premature ageing. Mouse models for human DNA repair deficiencies will be generated to assess the biological impact of these systems and for genotoxicity testing. The approaches followed include inducing specific DNA repair defects in the mouse germline by gene targeting technologies. Insight into DNA repair mechanisms is relevant for understanding the effect of DNA damage on vital processes such as transcription, replication and recombination. Indirectly these processes affect the origin of inborn defects, carcinogenesis, genome stability and ageing.
DNA repair has been traditionally a strong area in Europe and the current research project will introduce two Russian research groups to the European collaboration on DNA repair.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
3000 DR Rotterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.