Objective
Molecular determinants govern the intra- and intercellular communication of cells. The precise definition of distinct epitopes will thus provide suitable information on the status of cells that may explain their apparent functional activities, thereby opening up the possibility to turn the results of basic research into clinical benefit. Evidently, such knowledge would advance the panel of markers for tumour diagnosis and therapy.
Concomitant lines of research will make it possible to place emphasis on the glycobiological aspects of tumour cells: it is generally accepted that the sequence of carbohydrate chains of various cell constituents can store relevant biological information, decoded by endogenous receptors like lectins. The presence of such proteins and the possibility of modulatory responses to tumour parameters has recently in principle been ascertained. Current advances in carbohydrate synthesis provide access to any custom-made sugar component for measurement of respective lectin presence in sections of any tumour type by routine techniques. By combining the elaborate chemical synthesis of oligosaccharides with established cell biological and histopathological techniques, a new class of tumour markers (neoglycoconjugate) will be applied thoroughly to diverse classes of human cancer in order to elucidate, if possible, the correlation of expression of receptors for the tailored ligands with prognosis and propensity of metastasis formation. Common tumour classes like lung, breast, gastric, and colon malignancies will be screened.
Owing to the novelty of the interdisciplinary approach it is expected that the project will give a clear picture of the potential of these probes for routine practice.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
80539 München
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.