Objective
Following the rising world-wide incidence in recent years, tuberculosis has become again an important health risk and of major concern for the general public. The investigation of tuberculous infection and BCG vaccination in genetically defined mice strains will address fundamental questions about the nature and regulation of mandatory T cell immune responses. The obtained information will be important for the rational design of novel prophylactic vaccines. This will be based on the newly acquired knowledge about the structure of protective subunits, about the optimal conditions for imparting the highest degree of host resistance and about the cellular mechanisms required for the macrophage-mediated elimination of the tuberculous infection.
Two experimental models, previously established in the Moscow laboratory, will be used to investigate the genetic factors of the mouse H-2 and Tbc-1 loci, the cytokine profile and expression of adhesion molecules on T cells, the nature of the T cell-macrophage interactions and the macrophage mediated anti-tuberculous effector mechanisms. Comparison of the cellular parameters in BCG vaccinated mice will be interpolated for vaccinal strategies using the genetically permissive subunit constituents and avoiding those which are not recognised in the genetically defective individuals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
W12 0NN London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.