Objective
This research project is concerned with: the development of methods of organic synthesis and enzymatic optical activation of new systems with a superstable chiral pyramid; development of methodology of organic and bio-organic synthesis based on reagents with asymmetric nitrogen atoms; development of methods for chirality transfer from nitrogen to carbon and heteroatoms; study of the stereochemistry of reactions of the nitrogen atoms, including among other things Mannich and Michael reaction, nucleophilic substitution, and halogenation; synthesis of biologically active compounds with asymmetric nitrogen atoms and their investigation.
New classes of nitrogen containing organic compounds have been synthesized by the Russian group and methods of their resolution have been developed. Stable optically active compounds were obtained with an asymmetric centre solely at the nitrogen atom in three- and five-membered heterocycles and in open chain compounds.
The chemistry and the stereochemistry of these compounds will be studied. In addition, high level quantum-chemical studies will be carried out. The compounds to be synthesized and studied will be 1-fluoro- and 1-alkoxyaziridines, 2-fluoro- and 2- alkoxyaziridines, 7-fluoro- and 7-alkoxy-1, 7-diazanorbornanes; and the analogous acyclic compounds: N-fluoro-N-alkoxy-alkylamines, N-fluoro-N and N-dialkoxyamines.
The new compounds will be characterised by physical spectroscopic methods including photoelectron spectroscopy. The structure of interesting compounds will be investigated by gas-phase electron diffraction or x-ray analysis.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
45117 Essen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.