Objective
This research project is concerned with: the development of methods of organic synthesis and enzymatic optical activation of new systems with a superstable chiral pyramid; development of methodology of organic and bio-organic synthesis based on reagents with asymmetric nitrogen atoms; development of methods for chirality transfer from nitrogen to carbon and heteroatoms; study of the stereochemistry of reactions of the nitrogen atoms, including among other things Mannich and Michael reaction, nucleophilic substitution, and halogenation; synthesis of biologically active compounds with asymmetric nitrogen atoms and their investigation.
New classes of nitrogen containing organic compounds have been synthesized by the Russian group and methods of their resolution have been developed. Stable optically active compounds were obtained with an asymmetric centre solely at the nitrogen atom in three- and five-membered heterocycles and in open chain compounds.
The chemistry and the stereochemistry of these compounds will be studied. In addition, high level quantum-chemical studies will be carried out. The compounds to be synthesized and studied will be 1-fluoro- and 1-alkoxyaziridines, 2-fluoro- and 2- alkoxyaziridines, 7-fluoro- and 7-alkoxy-1, 7-diazanorbornanes; and the analogous acyclic compounds: N-fluoro-N-alkoxy-alkylamines, N-fluoro-N and N-dialkoxyamines.
The new compounds will be characterised by physical spectroscopic methods including photoelectron spectroscopy. The structure of interesting compounds will be investigated by gas-phase electron diffraction or x-ray analysis.
Topic(s)
Call for proposal
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45117 Essen
Germany