Objective
Among halogenated methanes there are significant industrial chemicals, pesticides and naturally occurring compounds. They are environmentally important not only because of their toxicity and/or carcinogenicity, but also because of their role in the destruction of the ozone layer. A collaborative study on the microbial degradation of the naturally occurring compounds chloromethane and bromomethane and of the industrial solvent dichloromethane will be carried out. These compounds are known to serve as carbon sources for aerobic methyltrophic bacteria. The occurrence of bacteria utilising halogenated methanes in the environment will be investigated as well as the biochemistry and the genetics of the dehalogenative enzymes, the key catalysts responsible for the degradation of halomethanes.
The research will focus on the enrichment and isolation of CH3Cl and CH2Cl2-degrading bacteria. The bacterieal isolates will be characterized physilogicaly. An in vitro assay for CH3Cl dehalogenase will be developed, and the CH3Cl dehalogenase will be purified and characterized. CH2Cl2 dehalogenase will be characterized from novel bacteria isolates. Taxonomic charaterisation of the selected methylotropic isolates and site-directed mutagenesis and experimental evolution of CH2Cl2 dehalogenase will be done. A nucleotide sequence of CH2Cl2 dehalogenase strucural genes from novel isolates will be established.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
8092 Zürich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.