Objective
Oncogenes may transform cells by affecting many components of the signal transduction pathway and/or inactivating tumour suppressor functions of cellular genes (Rb, p53). Activated Ha-ras oncogenes and tyrosine kinase oncogenes have been shown to affect the activity of transcription factors regulated through phosphorylation by MAP kinases. Viral oncogenes, like the adenovirus (Ad) E1A + E1B and the SV40 large T are supposed to transform cells mainly by binding to and inactivation of the Rb and p53 tumour suppressor activity.
The laboratory in Leiden will investigate what effect cell-transformation by the E1A gene has on the repertoire of active AP-1/ATF transcription factors. The Karlsruhe laboratory is involved in studies on the AP-1 transcription factors and the signal transduction pathways leading to the activation of these factors.
The laboratory in St. Petersburg has transformed rat embryo fibroblasts by various cytoplasmic and nuclear oncogenes which will be used to study whether these different types of oncogenes utilise to some extent common or non-overlapping mechanisms of cell transformation. The effects of the various oncogenes on the expression, activity, composition and regularity of transcription factors will lead to insight in the unique and the general pathways involved in cell-transformation. The cellular components used by these various pathways will be investigated for their effects on each other.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
2333 AL Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.