Objective
Chemical signals in the nervous system of flatworms are studied. Some classical neuronal signal systems have been discovered in simple organisms. Next to nothing is known about their appearence in evolution, functional role, its change in phylogeny and their relationship. The phylum Platyhelminthes is advantageous for this problem because these worms occupy a key position in evolution. They are the first animals with a central nervous system and with bilateral symmetry. They are well adapted to different environmental conditions, are free-living and parasitic, can reproduce sexually and asexually. The objectives of the project are: Identification of neuronal signal substances such as serotonin, neuropeptide F and free radical nitric oxide in flatworms of wide taxonomy range having different phylogenetical positions and from different ecological conditions. Isolation and sequencing of neuropeptides from different species of flatworms. Localization of the neural signal substances in different regions of the nervous system during different stages of the life cycle and regeneration. Investigation of the functional role of neuronal signal substances in development, reproduction and behaviour. Studies of the significance of neuronal signal substances in adaptation of flatworms to the environment. Elucidation of phylogenetic aspects of neuronal signal substances. The problem of neuronal chemical signals is in this project for the first time approached from many different angels and simultaneous with different methods by the 3 groups in Russia and 2 in INTAS countries. The experimental approaches are: immunocytochemistry on light and electron microscopy, confocal scanning laser microscopy, histochemistry, spectrofluorimetry, radiometry, sequencing of amino acides, microsurgery, morphometry, study of behaviour. The results of the project will give possibility to elucidate the morphofunctional mechanisms of development of flatworms from phylogenetical and ontogenetical positions. The results will play a role when solving fundamental problems of evolution of the nervous system, especially of the neuronal signal systems. In addition the results will help to use a new strategy in the control of parasites worldwide by methods which attack only the parasites and not their hosts.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project has not yet been classified with EuroSciVoc.
Be the first one to suggest relevant scientific fields and help us improve our classification service
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Data not available
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Data not available
Coordinator
20521 Turku/Abo
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.