Objective
The collaborating laboratories will develop antisense oligonucleotide constructs of a new generation, which will form very tight complexes with their target RNAs and will be capable of catalytically cleaving the target RNAs. Synthetic organic compounds mimicking catalytic centers of nucleases will be designed.
These will be the compounds bearing imidazole residues, carboxylic, guanidino- and amino groups. The RNA cleaving molles will be conjugated to oligonucleotide analogs capable of tight binding to specific target sequences: strong binding oligonucleotide analogs with modified bases and DNA aptamers tageted to specific elements of RNA structure.
Approaches will be developed to design antisense oligonucleotides for difficult RNA targets, which will be oligonucleotides capable of invading into the RNA structure. The developed oligonucleotide conjugates and methods will be applied to design of specific and efficient antisense oligonucleotide conjugates targeted to RNAs of important pathogens: viroids, ribosomal RNA of bacteria and mycoplasma, genomic and messenger RNA of influenza virus.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
97074 Wuerzburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.