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Content archived on 2024-05-27

Microprobe multi-sensor for graft viability monitoring during organ preservation and transplantation


This proposal seeks to provide the medical community with an innovative way for reliable monitoring of organs during transplantation. The monitoring, done using a purposely developed microsystem, would provide means for continuous evaluation of organ feasibility both during transport and postoperative initial evolution. To-date, the need for a perfect temperature and pathogen isolation of the organ during transport has been a major barrier in evaluating the needs and results of a constant monitoring. The recent development of silicon micro-biosensors opens a way in which to attain this objective without resigning to the mentioned organ isolation. Any action taken to increase the number of organs viable and improve their postoperative function shall be welcome by the European Society.

The proposed project intends to assist (1) the viability assessment of organs due for transplantation, expanding thus the number of available grafts and their possible destinies, and (2) the monitoring of organ behaviour during the initial postoperative period. The technological goal of this project is to raise awareness in the microsystems field through their use in a biomedical application that also requires a high level expertise on microelectronics design. Development of applications displaying these sort of needs and requiring these kind of solutions will contribute to enhance the European industry competitiveness broadening the market for both the silicon industries and the biomedical industries themselves

Work description:
The proposal will result in a new generation of medical devices for patient continuous monitoring. Through the use of available processes and microtechnologies quality of medical information and quality of assistance will be powered-up while reducing patient's risks and discomfort and hence, enhancing patients/ quality of life.

In order to provide the means for the above general objective, the following goals are proposed:
- To design, characterize and test a bio-sensing system for in-situ monitoring of he organ tissue, both during transport and initial postoperative evolution (tissue impedance, pH, K+ concentration and temperature will act as initial prognosis tools for the organ viability on the present proposal. Other, organ specific, parameters that should outlay a more selective prognosis for each organ will be studied and implemented within this project).
- To validate the feasibility and reliability of the system for in-situ monitoring of the chosen organ parameters.
- To investigate the usefulness of standard parameters in the prediction of organ viability.
- To study and test new and more effective parameters for prediction of organ viability and develop their corresponding micro-sensors.
- To analyse the real impact of the system's use.

The system will be implemented in two different outsets: a system for transport control in an adapted cryogenic chamber, and a system for bedside monitoring of the organ during postoperative evolution.
The actual outcome consist on a pre-industrial device able to organ monitoring during transport. This device is constituted by a multisensor core element which should be inserted in the organ. Signals obtained trough the sensoring device are conditioned by appropriated electronics, pre-processed and transmitted by RF operating at a public frequency out of the sterilized bags containing the organ. Measured parameters are received and externally processed through a commercial PALM that is in charge of display the main results and of firing alarms when needed. This device has been extensively proved. The latest experiments will begin at next September and it is expected to use it on humans at the beginning on next year (2004).


Call for proposal

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EU contribution
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28006 MADRID

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Total cost
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Participants (8)