Objective
G4-DNA is a stable linear DNA molecule made of consecutive planes of 4 guanine (G) bases connected with 4 poly-G strands. The aim of this project is to produce a novel G4-DNA wire with and without metal ions in the internal cores of G tetraplexes. A linear arrangement of redox-active ions in the centre line of the molecule will lead to the formation of a molecular wire by means of electron transfer or transport. The ability to incorporate metal ions with different contributions to the conduction properties into a single G4-DNA wire will enable the construction of wires composed of segments with high and low resistance regions along the conductor. The electrical transport properties of single G4-DNA wires will be studied by scanning tunnelling microscopy and spectroscopy and the conductivity along single G4-DNA molecules will be monitored by direct electrical transport measurements between metal nano-electrodes. The development of such molecular wires and devices may lay a basis for DNA-based Nano-electronics.
OBJECTIVES
The objective of this proposal is to develop G4-DNA-based nano-electronics. G4-DNA is a four-stranded structure that contains a planar arrangement of four guanine (G) nucleotides. We will produce conducting organic wires based on complexes of G4-DNA and also G4-DNA with metal-ions in the central space of each G4 plane. Electrical transport through single G4-DNA wires of different length and metal composition will be measured. Electronic conductivity of G4-DNA based wires will be altered by changing the nature of metal ions in the wire and the average distance between the neighbouring metal ions.
DESCRIPTION OF WORK
G4-DNA with and without different metal-ions will be prepared. The G4-DNA molecules will be deposited and attached to a metal surface. Scanning tunnelling microscopy and spectroscopy will be employed at temperatures ranging from room temperature down to cryogenic temperatures to study the electrical properties of single G4-DNA molecules. The electrical conductivity of these wires will be monitored by direct electrical transport measurements.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences electromagnetism and electronics
- natural sciences biological sciences genetics DNA
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences genetics nucleotides
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TEL AVIV
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.