Objective
This proposal was prepared with the help of an Exploratory award given to Bioma r SA and Loch Fyne Seafarms. The exploratory award covered a research feasibili ty study as well as novelty verification, economic assessment, partner search a nd the worprogramme definition. The project aims to provide new methods of supp ly of marine organisms for natural products drug research and development. It s eeks both to improve supply methods, ensuring both continuity of supply and red ucing the costs of drug development and production, and to replace the environm entally unsustainable need for collecting large quantities of marine invertebra tes from the wild. The technical risk is very high but justified in terms of the lucrative economic rewards for success and the social importance of improv ing the supply of new anti-cancer drugs. It will also boost European competitiv eness in an area largely dominated by the USA. The global state of the art in a ll the fields being examined is poor so the project has a high probability of m aking major advances beyond the state of the art even if it does not succeed in all its aims. A number of different and competing research avenues are being e xplored as there is no obvious predictable winner in terms of the technology most likely to succeed in securing supply. While this inevitably leads to some dissipation of effort it does improve the probability of hitting on one or more lines of commercially exploitable intellectual property rights (IPR). There are two major routes envisaged as possible methods of supply: aquaculture of i nvertebrate species producing interesting compounds; biosynthesis of compounds of interest by culturing invertebrate cells in bioreactors or the co-culturing of bacterial symbionts responsible for the production of anti-cancer compounds within the invertebrate. Both of these routes will be explored, concentrating o n an invertebrate species already known to contain a potent anti-cancer agent o f likely microbial origin and on a chemically defended species that is already being adapted for aquaculture use and may contain compounds of interest. The re search will consist of closing life cycle loops for aquaculture of these specie s and in developing methods of cell culture and co-culture of symbiotic bacteri a. Model species will be used to initially investigate feasible approaches. A v ariety of other species from Northern Europe, suitable for immediate aquacultur e production will also be screened for anti-cancer activity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- agricultural sciences agriculture, forestry, and fisheries fisheries
- engineering and technology environmental biotechnology bioremediation bioreactors
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
24231 ONZONILLA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.