Objective
The European Collaborative Study (ECS) on children born to human immunodeficiency virus (HIV) infected women is a multidisciplinary study of 19 centres with 1130 mother child pairs enrolled at the end of April 1992. The ECS has reported a rate of vertical transmission of 14.4%. Children born before 34 weeks gestation were more likely to be infected than were children who were breastfed. Transmission was high with vaginal deliveries in which episiotomy, scalp electodes, forceps or vacuum extractors were used but only in centres where these procedures were not routine. Transmission was not associated with maternal intravenous drug use, maternal age, race nor parity. There was no significant variation in transmission rates between centres. Although the relative importance of transmission at delivery is becoming apparent, prospective studies have shown similar rates of transmission in children delivered vaginally and by caesarian section (CS). There was some evidence of a protective effect of CS but the result was not statistically significant. Further research is needed to clarify the issue of transmission during labour and delivery. About one third of infected children develop acquired immune deficiency syndrome (AIDS) within the first year of life and 15% die of an HIV related death. The early onset of very rapidly progressive disease in a subset of children in the first 6 months of life needs further investigation. Although 90% of infected children show some manifestation of HIV infection before the age of 12 months, more children improve than deteriorate over the second and third year of life. The long term prognosis for infected children remains to be determined. Research is continuing on the clarification of the role of risk factors already identified, and the investigation of further risk factors for mother to child transmission of HIV infection.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 7HU London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.