The objective is to improve our knowledge of the tumour cell properties that influence the specific immune response of the host and also the ability of tumour cells to invade surrounding tissues and to metastasise. This should lead to the development of new treatment by increasing the specific host immune response and by inhibiting the invasive potential of tumour cells.
Central to this project is the obtention and storage of freshly collected tumour material and the development of permanent tumour cell lines on which both the cell surface properties relevant for metastasis and the tumour-specific antigens may then be studied in detail by all the participating centers. In a first step, the histology of the collected tumours will be restricted to melanomas, sarcomas, ovarian, breast and colon carcinomas. Tumour specimens, reagents and scientific knowledge will be exchanged. Patients with these types of tumours will be selected by the participating groups and attempts will be made by some of the group to establish permanent cell lines. These cell lines will then be sent back to all groups for specific studies of their invasion-related properties and of their immunogenecity to autologous T lymphocytes.